editorial
Tuesday, July 8th, 2008

 

Volume 29
June 2007
Number 3

 

   
Analytical and Quantitative Cytology and Histology
Reflection on the Past 2 Years

Rodolfo Montironi, M.D., FRCPath, and Roberta Mazzucchelli, M.D., Ph.D.
  
   
   
Analytical and Quantitative Cytology and Histology (AQCH) (formerly Analytical and Quantitative Cytology) was launched in 1979 with the mission of providing a high-quality publication venue for the rapid dissemination of novel and exciting advances in tumor and nontumor cytology and histology based on analytical and quantitative methods.
    The journal has grown in a rapid fashion by publishing a broad-based range of articles. Table I categorizes articles published by AQCH by general topic for publication years 2005–2006. Image analysis, flow cytometry, immunohistochemistry and advanced statistics, as well as human tumor pathology, related in particular to the urinary system and male genital organs, and human nontumor pathology continue to be significant components of articles published over these years. AQCH has also become the publication venue of studies describing new molecular and genetic findings of human cancers and of clinical studies demonstrating advances in risk assessment, detection, diagnosis and prognostic indications.
  

  
    The number of submissions and published articles has continually increased over the years, and, in 2 years, AQCH will enter its 30th year of publication. The success of AQCH has affirmed to the editorial board and editorial staff that there was and continues to be a significant need for a broad-based journal.
    AQCH is committed to meeting the challenges and emerging needs of the research scientific community. This commitment has been partly met through the establishment of a rapid online peer-review system, which has facilitated review of submitted articles, and the availability of the published articles in the pdf version (www.aqch.com). The latter allows for all articles to be made easily available to the scientific communities. This approach should provide authors using AQCH as their publication venue with maximal impact of their exciting research findings.
   
References
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  18. Mazzucchelli R, Barbisan F, Tarquini LM, Filosa A, Campanini N, Galosi AB: Gleason grading of prostate carcinoma in needle biopsies vs. radical prostatectomy specimens. Anal Quant Cytol Histol 2005;27:125–133
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  23. Durmus Z, Canel E, Kiliq E: Spectrofluorimetric assay of ciprofloxacin hydrochloride in tablets. Anal Quant Cytol Histol 2005;27:162–166
  24. Strik H, Luthe H, Nagel I, Ehrlich B, Bahr M: Automated cerebrospinal fluid cytology: Limitations and reasonable applications. Anal Quant Cytol Histol 2005;27:167–173
  25. Choi HJ, Choi IH, Kim TY, Cho NH, Choi HK: Three-dimensional visualization and quantitative analysis of cervical cell nuclei with confocal laser scanning microscopy. Anal Quant Cytol Histol 2005;27:174–180
  26. Ozcan A, Deveci MS, Oztas E, Dede M, Yenen MC, Korgun ET, Gunhan O: Prognostic value of GLUT-1 expression in ovarian surface epithelial tumors: A morphometric study. Anal Quant Cytol Histol 2005;27:181–186
  27. Celasun B, Mumcuoglu EU, Kalkan H: Sampling of sentinel lymph nodes: A simulation study. Anal Quant Cytol Histol 2005;27:187–194
  28. Frank DH, Davis JR, Ranger-Moore J, Liu Y, Bartels HG, Alberts DS, Bartels PH: Karyometry of infiltrating breast lesions. Anal Quant Cytol Histol 2005;27:195–201
  29. Lee JS, Choi YD, Choi C, Lee MC, Park CS, Min KW: Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth. Anal Quant Cytol Histol 2005;27:202–210
  30. Burke HB, Bostwick DG, Meiers I, Montironi R: Prostate cancer outcome: Epidemiology and biostatistics. Anal Quant Cytol Histol 2005;27:211–217
  31. Bollito ER, Pacchioni D, Lopez-Beltran A, Volante M, Terrone C, Casetta G, Mari M, DePompa R, Cappia S, Papotti M: Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder. Anal Quant Cytol Histol 2005;27:218–224
  32. Sanchez-Marin FJ: A simple procedure for simulating samples of tissue using Voronoi diagrams. Anal Quant Cytol Histol 2005;27:225–231
  33. Abu Eid R, Landini G: Morphometry of pseudoepitheliomatous hyperplasia: Objective comparison to normal and dysplastic oral mucosae. Anal Quant Cytol Histol 2005;27:232–240
  34. Uccella S, Tibiletti MG, Bernasconi B, Finzi G, Oldrini R, Capella C: Aneuploidy, centrosome alteration and securin overexpression as features of pituitary somatotroph and lactotroph adenomas. Anal Quant Cytol Histol 2005;27:241–252
  35. Us-Krasovec M, Erzen J, Zganec M, Strojan-Flezar M, Lavrencak J, Garner D, Doudkine A, Palcic B: Malignancy associated changes in epithelial cells of buccal mucosa: A potential cancer detection test. Anal Quant Cytol Histol 2005;27:254–262
  36. Lexander H, Palmberg C, Auer G, Hellstrom M, Franzen B, Jornvall H, Egevad L: Proteomic analysis of protein expression in prostate cancer. Anal Quant Cytol Histol 2005;27:263–272
  37. Nijhawan R, Rajwanshi A: Cytomorphologic and morphometric limitations of the assessment of atypia in fibroadenoma of the breast. Anal Quant Cytol Histol 2005;27:273–276
  38. Gazic B, Pizem J, Us-Krasovec M: Dilution effect of nontumor cells on flow cytometric DNA S-phase fraction in breast cancer fine needle aspirates. Anal Quant Cytol Histol 2005;27:277–283
  39. Dey P: Basic principles and applications of fractal geometry in pathology: A review. Anal Quant Cytol Histol 2005;27:284–290
  40. Wu HS, Xu R, Harpaz N, Burstein D, Gil J: Segmentation of microscopic images of small intestinal glands with directional 2-D filters. Anal Quant Cytol Histol 2005;27:291–300
  41. Emerson RE, Cheng L: Immunohistochemical markers in the evaluation of tumors of the urinary bladder: A review. Anal Quant Cytol Histol 2005;27:301–316
  42. Kipp BR, Fritcher EG, del Rosario KM, Stevens CL, Sebo TJ, Halling KC: A systematic approach to identifying urothelial cells likely to be polysomic by fluorescence in situ hybridization. Anal Quant Cytol Histol 2005;27:317–322
  43. Bartels PH, Descour M, Alberts DS, Ranger-Moore J: The evolution of scanning microphotometry: A historical review. Anal Quant Cytol Histol 2005;27:323–336
  44. Misra JS, Das V, Srivastava AN, Singh U, Singh M: AgNOR counts in cervical smears under normal and other cytopathologic conditions. Anal Quant Cytol Histol 2005;27:337–340
  45. Adley BP, Yang XJ: Application of alpha-methylacyl coenzyme A racemase immunohistochemistry in the diagnosis of prostate cancer: A review. Anal Quant Cytol Histol 2006;28:1–13
  46. Kahn E, Vejux A, Menetrier F, Maiza C, Hammann A, Sequeira-Le Grand A, Frouin F, Tourneur Y, Brau F, Riedinger JM, Steinmetz E, Todd-Pokropek A, Lizard G: Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots: Investigation by flow cytometry and spectral imaging microscopy. Anal Quant Cytol Histol 2006;28:14–26
  47. Kayser G, Radziszowski D, Bzdyl P, Sommer R, Kayser K: Theory and implementation of an electronic, automated measurement system for images obtained from immunohistochemically stained slides. Anal Quant Cytol Histol 2006;28:27–38
  48. Katona TM, Shienbaum AJ, Wyatt LL, Brown GA, Cheng L: Malignant fibrous histiocytoma of the glans penis: A case report. Anal Quant Cytol Histol 2006;28:39–42
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  50. Razga Z, Randel Nyengaard J: A stereologic approach to estimate the number of immunogold-labeled molecules in cells of tubules. Anal Quant Cytol Histol 2006;28:54–60
  51. Scartozzi M, Pierantoni C, Berardi R, Antognoli S, Bearzi I, Cascinu S: Epidermal growth factor receptor: A promising therapeutic target for colorectal cancer. Anal Quant Cytol Histol 2006;28:61–68
  52. Nafe R, Yan B, Schlote W, Schneider B: Application of different methods for nuclear shape analysis with special reference to the differentiation of brain tumors. Anal Quant Cytol Histol 2006;28:69–77
  53. Boon ME, Berger TH, Middag-Broekman AJ, Kok LP: Optimized quality of histologic images allows the use of neural network scanning in diagnosis of fungal infection of abnormal nails. Anal Quant Cytol Histol 2006;28:78–86
  54. Nieuwenhuizen L, Khalil MK, Venkatesh N, Othman NH: Endometrial and endocervical secretion: The search for histochemical differentiation. Anal Quant Cytol Histol 2006;28:87–96
  55. Nyagol J, Nyong'o A, Byakika B, Muchiri L, Cocco M, de Santi MM, Spina D, Bellan C, Lazzi S, Kostopoulos I, Luzi P, Leoncini L: Routine assessment of hormonal receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer. Anal Quant Cytol Histol 2006;28:97–103
  56. Samaratunga H, Gardiner RA, Yaxley J, Brown I: Atypical prostatic glandular proliferations on needle biopsy: Diagnostic implications, use of immunohistochemistry, and clinical significance. Anal Quant Cytol Histol 2006;28:104–110
  57. Lopez-Beltran A, MacLennan GT, Montironi R: Cyclin E as molecular marker in the management of breast cancer: A review. Anal Quant Cytol Histol 2006;28:111–114
  58. Zheng WQ, Ma R, Zheng JM, Gong ZJ: Elastin distribution in the normal uterus, uterine leiomyomas, adenomyosis and adenomyomas: a comparison. Anal Quant Cytol Histol 2006;28:115–120
  59. Matsuda T, Fujime M, Suda K: Relationship between the prostatic tissue components and natural history of benign prostatic hyperplasia. Anal Quant Cytol Histol 2006;28:121–124
  60. Zhou M, Magi-Galluzzi C, Epstein JI: Prostate basal cell lesions can be negative for basal cell keratins: A diagnostic pitfall. Anal Quant Cytol Histol 2006;28:125–129
  61. Rocher AE, Gonzalez A, Palaoro LA, Blanco AM: Usefulness of AgNOR technique and CEA expression in atypical metaplastic cells from cervical smears. Anal Quant Cytol Histol 2006;28:130–136
  62. Bearzi I, Mandolesi A, Arduini F, Costagliola A, Ranaldi R: Gastrointestinal stromal tumor: A study of 158 cases: Clinicopathological features and prognostic factors. Anal Quant Cytol Histol 2006;28:137–147
  63. Zeppa P, Marino G, Lepore M, Troncone G, Lupoli GA, Biondi B, Picardi M, Pane F, Vetrani A, Palombini L: Flow cytometry phenotypization of thyroidal lymphoid infiltrate and functional status in Hashimoto's thyroiditis. Anal Quant Cytol Histol 2006;28:148–156
  64. del Vecchio MT, Epistolato MC, Tripodi SA, Montironi R, Giordano A: Intratubular germ cell neoplasia of unclassified type. Anal Quant Cytol Histol 2006;28:157–170
  65. Gammon RR, Kharazi M, Brandt JT, Keyhani-Rofagha S: Correlation between the Papanicolaou stain and the Wright-Giemsa stain in body fluids: A quality assurance study. Anal Quant Cytol Histol 2006;28:171–174
  66. Pawitan JA, Suryono IA: Sensitivity and specificity of the micronucleus test in hypotonic-swollen mononuclear leukocytes compared to the micronucleus test in binucleated lymphocytes to assess chromosomal breaks. Anal Quant Cytol Histol 2006;28:175–180
  67. Iczkowski KA, Butler SL: New immunohistochemical markers in testicular tumors. Anal Quant Cytol Histol 2006;28:181–187
  68. Camargo RS, Shirata NK, di Loreto C, Garcia EA, Castelo A, Longatto Filho A: Significance of AgNOR measurement in thyroid lesions. Anal Quant Cytol Histol 2006;28:188–192
  69. Katona TM, Lopez-Beltran A, MacLennan GT, Cheng L, Montironi R, Cheng L: Soft tissue tumors of the penis: A review. Anal Quant Cytol Histol 2006;28:193–206
  70. Aktug H, Uslu S, Terek MC, Terzi H, Turgut M, Ozsener S, Bilgin O: Effects of ovariectomy and tamoxifen on rat bone tissue: Histomorphometric and histopathologic study. Anal Quant Cytol Histol 2006;28:207–212
  71. Chowdhury N, Pai MR, Lobo FD, Kini H, Varghese R: Interobserver variation in breast cancer grading: A statistical modeling approach. Anal Quant Cytol Histol 2006;28:213–218
  72. Auada MP, Adam RL, Leite NJ, Puzzi MB, Cintra ML, Rizzo WB, Metze K: Texture analysis of the epidermis based on fast Fourier transformation in Sjögren-Larsson syndrome. Anal Quant Cytol Histol 2006;28:219–227
  73. Adley BP, Papavero V, Sugimura J, Teh BT, Yang XJ: Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. Anal Quant Cytol Histol 2006;28:228–236
  74. Demiriz M, Kurumlu Z, Celasun B, Gunhan O: A simple method for the evaluation of epidermal thickness variations in psoriasis vulgaris. Anal Quant Cytol Histol 2006;28:237–242
  75. Bartels PH, Ranger-Moore J, Alberts D, Hess L, Scarpelli M, Montironi R: Carcinogenesis and the hypothesis of phylogenetic reversion. Anal Quant Cytol Histol 2006;28:243–252
  76. Model MA, Blank JL: Intensity calibration of a laser scanning confocal microscope based on concentrated dyes. Anal Quant Cytol Histol 2006;28:253–261
  77. Rode M, Flezar MS, Kogoj-Rode M, Us-Krasovec M: Image cytometric evaluation of nuclear texture features and DNA content of the reticular form of oral lichen planus. Anal Quant Cytol Histol 2006;28:262–268
  78. Klimek I, Kaluzynski A, Kulig A, Szymczak W, Ambroziak R: Glomerular basement membrane thinning in children: A morphometric assessment. Anal Quant Cytol Histol 2006;28:269–280
  79. Markiewicz T, Osowski S, Patera J, Kozlowski W: Image processing for accurate cell recognition and count on histologic slides. Anal Quant Cytol Histol 2006;28:281–291
  80. Nair BC, Kumar S, Rani S, Paliwal OP: Analysis of karyometric variables in spontaneously occurring canine mammary tumors. Anal Quant Cytol Histol 2006;28:292–296
  81. Petroff BK, Phillips TA, Kimler BF, Fabian CJ: Detection of biomarker gene expression by real-time polymerase chain reaction using amplified ribonucleic acids from formalin-fixed random periareolar fine needle aspirates of human breast tissue. Anal Quant Cytol Histol 2006;28:297–302
  82. Yalcin B, Arda N, Tezel GG, Erman M, Alli N: Expressions of vascular endothelial growth factor and CD34 in oral aph­thous lesions of Behçet's disease. Anal Quant Cytol Histol 2006;28:303–306
  83. Wu HS, Salzberg SP, Gil J: Automatic image segmentation with linear clustering for quantification of neointimal formation after surgical vein grafting. Anal Quant Cytol Histol 2006;28:307–315
  84. Kahn E, Menetrier F, Vejux A, Montange T, Dumas D, Riedinger JM, Frouin F, Tourneur Y, Brau F, Stoltz JF, Lizard G: Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7–ketocholesterol-treated human monocytic cells. Anal Quant Cytol Histol 2006;28:316–330
  85. Han U, Adabag A, Koybasioglu F, Onal BU: Clinical value of cell counts and indices in testicular fine needle aspiration cytology in primary infertility: Diagnostic performance compared with histology. Anal Quant Cytol Histol 2006;28:331–336
  86. Davidson DD, Cheng L: “Field cancerization” in the urothelium of the bladder. Anal Quant Cytol Histol 2006;28:337–338
  87. Lopez-Beltran A: Urothelial changes induced by therapeutic procedures for bladder cancer. Anal Quant Cytol Histol 2006;28:339
  88. Mazzucchelli R, Tuna B: Noninvasive urothelial neoplasms: Which classification? Anal Quant Cytol Histol 2006;28:340
  89. Model MA, Blank JL: Difference between mean and threshold as a measure of intensity in confocal microscopy images. Anal Quant Cytol Histol 2006;28:341–343
  90. Bargaje A, Venkataraman G, Flanigan R, Wojcik EM, Ananthanarayanan V: Utility of prostate biopsy morphometric sum optical density for identifying extraprostatic extension on subsequent prostatectomy. Anal Quant Cytol Histol 2006;28:343–345
  91. van Bogaert LJ: Sampling of sentinel nodes: A simulation study. Anal Quant Cytol Histol 2006;28:345–346
  92. Vidal-Jimenez A: Gleason grading of prostate cancer in needle biopsies vs. radical prostatectomy specimens. Anal Quant Cytol Histol 2006;28:340–341

Keywords: AQCH, cytology, histology, tumor. (Anal Quant Cytol Histol 2007;29:123–127)

From the Section of Pathologic Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.

Address correspondence to: Rodolfo Montironi, M.D., FRCPath, Section of Pathologic Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I–60020 Torrette, Ancona, Italy (r.montironi@univpm.it).

Financial Disclosure: The authors have no connection to any companies or products mentioned in this editorial.



  
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