Sunday, March 18th, 2018


Protective Effect of Potentilla fulgens on Changes in Cerebellum Following Traumatic Head Injury
Authors:  Ozevren Hüseyin, M.D., Irtegün Sevgi, Ph.D., and Deveci Engin, Ph.D.
  Objective: To examine protective effects of Potentilla fulgens (P. fulgens) extract on cerebellar tissue damage of head-traumatized rats with respect to biochemical, histopathological, immunohistochemical, and ultrastructural analysis.
Study Design:
Sprague-Dawley rats were subjected to traumatic head injury with a weight-drop device using 300 g–1 m weight–height impact. In our study the occipital lobe region was subjected to moderate trauma. Sixty-four rats were divided into 4 groups: group 1 (control group), group 2 (P. fulgens group [400 mg/kg/day i.p.]), group 3 (trauma group), and group 4 (trauma+P. fulgens [400 mg/kg/day i.p.]). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. fulgens were evaluated by histological, immunohistochemical, and biochemical analyses.
After trauma, degenerative changes and congestion were observed in Purkinje and glial cells. Elevated expression of E-cadherin in synaptic junctions, increased tumor necrosis factor alpha expression in Purkinje and glial cells, and elevated endothelin-1 expression in vessel endothelium were observed. Ultrastructural analysis showed loss of mitochondrial crista, and dilation of endoplasmic reticulum of Purkinje cells was observed.
Although further studies are necessary to evaluate the time- and dose-dependent neuroprotec-tive effects of P. fulgens, it may be a beneficial therapeutic agent for prevention of cerebellar damage following diffuse traumatic head injury.
Keywords:  cerebellum; Cinquefoil; head injury, blunt; head trauma; Potentilla; rat; Silverweed
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