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Title:
Pterostilbene Attenuates Inflammation in Rat Heart Subjected to Ischemia-Reperfusion via eNOS Activation
Authors:  Zhe Zhang, Ph.D., Bei-jie Ma, B.S., Liang-tong Li, B.S., Hui-qin Wang, B.S., and Ning Zhu, M.D.
  Objective: To investigate whether pterostilbene could activate eNOS and reduce neutrophil accumulation and tumor necrosis factor α (TNF-α) induction in an ischemia/reperfusion injured rat heart model.
Study Design:
Rats were randomly exposed to sham operation, myocardial ischemia and reperfusion (MI/R), MI/R+pterostilbene, or MI/R+pterostilbene+L-NAME. Myocardial infarct size, apoptosis, TLR4 expression, NF-κB expression, myeloperoxidase (MPO) level, and TNF-α level were detected.
Results:
The results demonstrated that after MI/R, the expressions of myocardial TLR4, NF-κB, and caspase-3 increased significantly in the ischemia area. Compared with MI/R, pterostilbene significantly attenuated the expressions of TLR4, NF-κB, and caspase-3. In addition, it also reduced MPO levels, both serum and myocardial TNF-α production, myocardial infarct sizes (INF/AAR%), and myocardial apoptosis induced by MI/R. All the effects of pterostilbene were abolished by L-NAME, a nitric oxide synthase inhibitor.
Conclusion:
These data provide evidence that pterostilbene inhibits inflammation and apoptosis in the rat heart subjected to MI/R via eNOS activation.
Keywords:  apoptosis, Enos, ischemia/reperfusion injury, neutrophil, pterostilbene, TNF-α
   
   
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