Wednesday, November 14th, 2018

 

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Title:
Association of 2 Polymorphisms in Transforming Growth Factor Beta 1 and Their Effect on the Risk of Acute Liver Graft Rejection
Authors:  Lianying Yu, M.D., Yue Zhang, M.D., Ph.D., Li Xu, M.D., Qiyi Wang, M.D., Ph.D., Weihong Sha, M.D., Ph.D., and Hong Gang Ren, M.D., Ph.D.
  Objective: To investigate the association of the transforming growth factor beta 1 (TGF-β1) polymorphism with acute liver graft rejection (AR) and to conduct a comprehensive analysis encompassing all relevant studies, which have shown conflicting results over the past years.
Study Design:
A systematic literature was done for articles assessing the association between TGF-β1 polymorphism and AR. The OR and 95% CI were applied to investigate the strength of the associations.
Results:
Overall, the pooled analysis showed a null association between TGF-T869C and AR, with ORs (95% CIs) of 1.13 (0.60–2.12) for TT versus CC. G915C was negatively associated with AR, and the ORs (95% CIs) were 0.91 (0.29–2.86) for G carrier versus CC. For subgroup analyses according to ethnicity, results indicated that TGF-T869C was not associated with risk of AR for either Asians (1.21 [0.64–2.31] for T carrier versus CC) or Caucasians (1.27 [0.76–2.10] for T carrier versus CC). G915C was also not associated with risk of AR for Caucasians (0.91 [0.29–2.186] for G carrier versus CC).
Conclusion:
Our study suggests that TGF β-T869C and G915C may have a null association with AR risk. The above findings reinforce the need for further and more rigorous association studies.
Keywords:  acute rejection; cytokine gene polymorphisms; graft rejection; grafting, liver; hepatic transplantation; liver; liver transplantation; meta-analysis; TGF-beta1; transforming growth factor beta1; transplant rejection; transplantation rejection
   
   
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