Monday, September 24th, 2018

 

Next
A full text version of this article is available.
To access article obtain online access here or login
 
Title:
HPV L1 Capsid Protein Is Suitable for Distinguishing CIN 2/3 and Cancer from CIN 1 Rather Than from CIN 1 and Lower Conditions
Authors:  Lan Chen, M.M., Xuming Wang, Ph.D., Limian Song, M.M., Dujuan Yao, M.M., Qianqian Tang, M.M., and Jun Zhou, M.D.
  Objective: To evaluate the value of HPV L1 capsid protein applied in diagnosing high-grade cervical intraepithelial neoplasia (CIN 2/3) and cancer.
Study Design:
A total of 232 patients with HPV-positive or abnormal cervical cytology higher than atypical squamous cells of undetermined significance (ASC-US) or both items positive were enrolled. HPV L1 capsid protein was detected with immunocytochemistry. The value of HPV L1 capsid protein applied in diagnosing CIN 2/3 and cancer was evaluated.
Results:
The expression rate of HPV L1 capsid protein decreased with increasing CIN grade from CIN 1 to CIN3 and cervical cancer and was negatively correlated with CIN grade. The diagnostic value of HPV L1 capsid protein was higher in distinguishing CIN 2/3 and cervical cancer from CIN 1 than from normal cervical cells/chronic cervicitis cells and CIN 1. The specificity, accuracy, and positive predictive value (PPV) were higher in distinguishing CIN 2/3 and cervical cancer from CIN 1 than in distinguishing CIN 2/3 and cervical cancer from normal cervical cells/chronic cervicitis cells and CIN 1, and the false positive rate (FPR) was lower.
Conclusion:
HPV L1 capsid protein is suitable for distinguishing CIN 2/3 and cancer from CIN 1 rather than from low-grade CIN and lower conditions.
Keywords:  cervical cancer, cervical intraepithelial neoplasia, diagnostic value, HPV L1 capsid protein, immunocytochemistry
   
   
  Acrobat Reader 7.0 is recommended to properly view and print the article.
Reader can be downloaded from