Tuesday, May 26th, 2020


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RRBP1 Expression in Paired Central and Peripheral Astrocytoma Tissue Microarray
Authors:  Yan Li, M.D., Ph.D., Baoshi Han, M.D., Youqiang Cui, M.D., Guangcun Liu, M.D., Ph.D., and Xianzeng Hou, M.D., Ph.D.
  Objective: To develop new therapeutic targets for astrocytoma and explore potential mechanisms regulating astrocytoma relapse.
Study Design:
Expression of RRBP1, MMP9, and Ki-67 was investigated at the center and periphery of astrocytoma tissues.
RRBP1 expression was higher in peripheral than in central astrocytoma tissues, although the difference was not statistically significant. RRBP1 expression was significantly correlated with that of proliferative marker Ki-67 and invasive marker MMP9.
These results indicate that high RRBP1 expression may regulate astrocytoma proliferation and invasion. However, further investigation is needed to elucidate the underlying potential mechanisms.
Keywords:  astrocytoma; brain cancer; brain neoplasms, malignant; cell proliferation; glioblastoma; MMP9; matrix metalloproteinase 9; neoplasm invasion; ribosome binding protein 1; ribosomal proteins; RRBP1
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