Saturday, September 26th, 2020


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SNHG7 Expression Is Upregulated in Ovarian Cancer and Promotes Cell Invasion and EMT Pathway
Authors:  Mingli Dong, M.D., Zhennan Dong, M.D., Xinyu Zhu, M.D., Yunhe Zhang, M.D., and Lei Song, M.D.
  Objective: Long non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) has been identified as an oncogene in tumor progression. However, the role of SNHG7 in ovarian cancer remains unknown.
Study Design:
The expression of circ SNHG7 was detected in human ovarian cancer tissue and adjacent normal tissue samples using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses. The chi-squared test was used to assess the association between expression of SNHG7 and clinical pathological parameters. Cell proliferation and invasion were performed by CCK8 and transwell assays. Western blot analysis was used to detect the protein expression.
We demonstrated that SNHG7 was significantly upregulated in human ovarian cancer tissues and cells. Higher SNHG7 expression was associated with clinical stage and lymph node metastasis. Furthermore, we demonstrated that knockdown of SNHG7 inhibited cell proliferation and cell invasion ability. Additionally, we observed that knockdown of SNHG7 suppressed the cell epithelial-mesenchymal transition (EMT) process by upregulating E-cadherin expression but downregulating MMP9 expression.
These results indicated that SNHG7 expression was higher in ovarian cancer tissues and promoted cell invasion and EMT process, which may serve as a target of ovarian cancer treatment.
Keywords:  cell invasion, epithelial-mesenchymal transition, lncRNA; neoplasm invasiveness, ovarian cancer, ovary cancer, long noncoding RNA, metastasis, SNHG7
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