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Title:
Comparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-α in Systemically Healthy Chronic Periodontitis Patients: A Non-Randomized Clinical Trial
Authors:  Arzum Güler Dogru, Ph.D., Ömer Toprak, Ph.D., Devrim Deniz Üner, Ph.D., Bozan Serhat Izol, Ph.D., Ibrahim Kaplan, Ph.D., Mehmet Dogru, Ph.D., and Fikret Ipek, Ph.D.
  Objective: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) in patients with chronic periodontitis.
Study Design:
The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (≥5 mm) periodontal pocket in the posterior region of each upper left hemi-arcade. The study was designed as a split-mouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side.
Results:
A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF-α levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF-α levels in the hemi-arcade treated with laser diode contamination therapy, whereas the changes in the hemi-arcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A between-group comparison revealed no statistically significant difference at 3 months post- therapy, while the difference at 1 month was found to be statistically significant. proinflammatory TNF-α levels in the early period but makes no contribution in the long term.
Keywords:  chronic periodontitis, dental plaque, dental scaling, dental surgery, diode laser, gingival crevicular fluid, lasers, nonsurgical periodontal therapy, periodontal attachment loss, periodontal diseases, periodontal pocket, periodontitis, TNF-α, tumor necrosis factor alpha
   
   
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